首都医科大学附属北京世纪坛医院
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曾辉研究员

擅长:

免疫学。

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个人简介 学术任职 主研方向 获奖情况 学术论著

[职称] 研究员,教授

[职务] 生物医学创新中心主任

[学位] 生物学博士、医学博士

教育背景/工作经历

1988-1993 首都医科大学临床医学学士

1993-1996 首都医科大学临床医学硕士

2000-2004 德国杜伊斯堡-埃森大学生物学博士 ( Ph.D./Dr.rer.nat. )

2004-2006 德国杜伊斯堡-埃森大学医学博士 ( M.D./Dr. Med.)

1996-1998 首都医科大学附属北京同仁医院血液内科, 住院医师、主治医师

1998-2000 美国华盛顿大学医学院血液科Senior research fellow

2004-2006 德国杜伊斯堡-埃森大学,博士后

2006-2021 首都医科大学附属北京地坛医院,研究员、教授,传染病研究所副所长、所长

2021年4月至今 首都医科大学附属北京世纪坛医院生物医学创新中心主任

中国医师协会体外生命支持专业委员常务委员兼总干事

中国性病艾滋病防治协会艾滋病病毒学专业委员会 委员

新发突发传染病北京市重点实验室副主任

国家中医药管理局三级实验室(感染免疫)主任

主要关注炎症与免疫系统发育和免疫应答调控。北京市高层次创新创业人才支持计划卫生领军人才、北京市卫生系统高层次人才培养感染免疫方向学科带头人。主持国家自然科学基金资助7项,作为第一作者和责任作者文章在Nature Communications、Molecular Cell、Cell Reports、Annals of Internal Medicine、EMBO Journal、National Science Review、Blood、British Journal of Hematology、Thorax、Clinical Cancer Research、Clinical Infectious Disease、Journal of Infectious Diseases, Aging Cell、Critical Care 、Signal Transduction and Targeted Therapy、AIDS等多学科领域发表论文。

2021 华夏医学科技奖二等奖

2020 北京市科学技术进步奖二等奖

2018华夏医学科技奖二等奖

2017中华医学科技奖二等奖

2016北京市科学技术进步奖三等奖

1998北京市科学技术进步奖三等奖

作为第一作者和责任作者文章在Nature Communications、Molecular Cell、Cell Reports、Annals of Internal Medicine、EMBO Journal、National Science Review、Blood、British Journal of Hematology、Thorax、Clinical Cancer Research、Clinical Infectious Disease、Journal of Infectious Diseases, Aging Cell、Critical Care 、Signal Transduction and Targeted Therapy、AIDS等多学科领域发表论文。

代表性论文:

1) Li J, Du P, Yang L, Zhang J, Song C, Chen D, Song Y, Ding N, Hua M, Han K, Song R, Xie W, Chen Z, Wang X, Liu J, Xu Y, Gao G, Wang Q, Pu L, Di L, Li J, Yue J, Han J, Zhao X, Yan Y, Yu F, Wu AR, Zhang F, Gao YQ, Huang Y, Wang J, Zeng H, Chen C. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022, 38:110205.

2) Zhang J, Ding N, Song Y, Song R, Pan Y, Wang L, Yan S, Wang Q, Ma S, Wei L, Yu F, Lu L, Zhang F, Chen C, Zeng H*. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (NY). 2021, 2:100099.

3) Zhang Y, Han K, Du C, Li R, Liu J, Zeng H*, Zhu L, Li A. Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients. Crit Care. 2021, 25:51.

4) Zhang J, Ding N, Ren L, Song R, ChenD, Zhao X, Chen B, Han J, Li J, Song Y, Di L, Han K, Yu F, Xie R, Chen Z, Xie W, Liu J, Cen S, Bi Y, Wu RA, Zhang F, Chen C, Zeng H*. COVID-19 reinfection in the presence of neutralizing antibodies. Natl Sci Rev. 2021, 8: nwab006

5) Chen C, Li J, Di L, Jing Q, Du P, Song C, Li J, Li Q, Cao Y, Xie XS, Wu AR, Zeng H*, Huang Y, Wang J. MINERVA: A facile strategy for SARS-CoV-2 whole genome deep sequencing of clinical samples. Mol Cell. 2020, 80:1123-1134. (IF: 15.584)

6) Du P, Song C, Li R, Song Y, Li J, Ding N, Zhang J, Song R, Han J, Gao G, Yue J, Duan A, Huang Y, An J, Wang J, Zhang F, Chen C, Zeng H*. Specific re-distribution of SARS-CoV-2 variants in the respiratory system and intestinal tract. Clin Infect Dis. 2020 Oct 22:ciaa1617. doi: 10.1093/cid/ciaa1617. (IF: 8.313)

7) Du P, Ding N, Li J, Zhang F, Wang Q, Chen Z, Song C, Han K, Xie W, Liu J, Wang L, Wei L, Ma S, Hua M, Yu F, Wang L, Wang W, An K, Chen J, Liu H, Gao G, Wang S, Huang Y, Wu AR, Wang J, Liu D, Zeng H*, Chen C. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun. 2020, 11:5503. (IF: 12.121)

8) Kong Y, Wang Y, Wu X, Han J, Li G, Hua M, Han K, Zhang H, Li A, Zeng H*. Storm of soluble immune checkpoints associated with disease severity of COVID-19. Signal Transduct Target Ther. 2020, 5:192. (IF: 13.493)

9) Chen C, Gao G, Xu Y, Pu L, Wang Q, Wang L, Wang W, Song Y, Chen M, Wang L, Yu F, Yang S, Tang Y, Zhao L, Wang H, Wang Y, Zeng H*, Zhang F. SARS-CoV-2-positive sputum and feces after conversion of pharyngeal samples in patients with COVID-19. Ann Intern Med. 2020, 172:832-834. (IF: 21.317)

10) Zhang N, Zhu L, Zhang Y, Zhou C, Song R, Yang X, Huang L, Xiong S, Huang X, Xu F, Wang Y, Wan G, Chen Z, Li A, Zhan Q, Zeng H. Circulating rather than alveolar extracellular DNA levels predict outcomes in influenza: a cohort study. J Infect Dis. 2020 222:1145-1154. (IF: 5.022)

11) Zhao C, Jia B, Wang M, Schell TD, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Songdej N, Sivik JM, Hohl RJ, Zeng H*, Zheng H. Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML. Br J Haematol. 2020,188:674-684. (IF: 5.518)

12) Kong Y, Jia B, Zhao C, Claxton DF, Sharma A, Annageldiyev C, Fotos JS, Zeng H, Paulson RF, Prabhu KS, Zheng H. Downregulation of CD73 associates with T cell exhaustion in AML patients. J Hematol Oncol. 2019, 12:40.

13) Li J, Du P, Ye AY, Zhang Y, Song C, Zeng H*, Chen C*. GPA: A Microbial Genetic Polymorphisms Assignments Tool in Metagenomic Analysis by Bayesian Estimation. Genom Proteom Bioinf. 2019, 17:106-117.

14) Chen C, Jiang D, Ni M, Li J, Chen Z, Liu J, Ye H, Wong G, Li W, Zhang Y, Wang B, Bi Y, Chen D, Zhang P, Zhao X, Kong Y, Shi W, Du P, Xiao G, Ma J, Gao GF, Cui J, Zhang F, Liu W, Bo X, Li A, Zeng H*, Liu D. Phylogenomic analysis unravels evolution of yellow fever virus within hosts. PLoS Negl Trop Dis. 2018,12:e0006738. (IF: 3.885)

15) Song Y, Wang B, Song R, Hao Y, Wang D, Li Y, Jiang Y, Xu L, Ma Y, Zheng H, Kong Y*, Zeng H*. T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenscence. Aging Cell. 2018 17:e12716. (IF: 7.238)

16) Zhu L, Liu L, Zhang Y, Pu L, Liu J, Li X, Chen Z, Hao Y, Wang B, Han J, Li G, Liang S, Xiong H, Zheng H, Li A, Xu J*, Zeng H*. High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection. J Infect Dis. 2018, 217:428-437. (IF: 5.022)

17) Zhu L, Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Palmisiano ND, Wang M, Jia B, Bayerl M, Schell TD, Hohl RJ, Zeng H*, Zheng H. Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia. J Hematol Oncol. 2017, 10:124.

18) Xing Z, Han J, Hao X, Wang J, Jiang C, Hao Y, Wang H, Shen L, Dong X, Li T, Li G, Zhang J, Hou X*, Zeng H*. Immature monocytes contribute to cardiopulmonary bypass-induced acute lung injury by generating inflammatory descendants. Thorax, 2017, 72: 245-255.

19) Kong Y, Li Y, Zhang W, Yuan S, Winkler R, Kröhnert U, Han J, Lin T, Zhou Y, Miao P, Wang B, Zhang J, Yu Z, Zhang Y, Kosan C, Zeng H*. Sepsis-induced thymic atrophy is associated with defects in early lymphopoiesis. Stem Cells. 2016, 34:2902-2915.

20) Kong Y, Zhu L, Schell TD, Zhang J, Claxton DF, Ehmann WC, Rybka W, George MR, Zeng H*, Zheng H. TIGIT associates with CD8+ T cell exhaustion and poor clinical outcome in AML patients. Clin Cancer Res. 2016 22:3057-66.

21) He G, Zhang H, Zhou J, Wang B, Chen Y, Kong Y, Xie X, Wang X, Fei R, Wei L1, Chen H, Zeng H*. Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2015, 18:141.

22) Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Zhu L, Zeng H, Schell TD, Zheng H. PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer J. 2015, 5:e330.

23) Hou X*, Yang X, Du Z, Xing J, Li H, Jiang C, Wang J, Xing Z, Li S, Li X, Yang F, Wang H and Zeng H*. Superior vena cava drainage improves upper body oxygenation during veno-arterial extracorporeal membrane oxygenation in sheep. Crit Care 2015, 19:68.

24) Zhu L#, Meng Q#, Liang S, Ma Y, Li R, Li G, Zeng H*. The transcript.on factor GFI1 negatively regulates NLRP3 inflammasome activation in macrophages. FEBS Lett. 2014, 588:4513-4519.

25) Shi G#, Han J#, Liu G, Hao Y, Ma Y, Li T, Wu X, Zhang H, Liu Y, Wang B, Kong Y, Zhou J*, Zeng H*. Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients. Eur J Immunol. 2014, 44:420-430.

26) Zhou H#, Zhao H#, Hao Y#, Song C, Han J, Zhang J, Gao G, Han N, Yang D, Li Y, Zhang F, Zeng H *. Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 counts. AIDS. 2013, 27:1059-1069.

27) Hou J, Sun Y*, Hao Y, Zhuo J, Liu X, Bai P, Han J, Zheng X, Zeng H *. Imbalance between subpopulations of regulatory T cells in COPD. Thorax. 2013, 68: 1131-1139.

28) Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Hébert J, Zeng H* and Möröy T*. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells. 2011, 29: 376-385.

29) Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H*, MöröyT*. Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol. 2010, 30:3929-3942.

30) Zeng H, Yucel R, Kosan C, Klein-Hitpass L, Möröy T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004, 23:4116.

31) Karsunky H, Zeng H, Schmidt T, Zevnic B, Kluge R, Schimid KW, Duhrsen U, Möröy T. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002, 30:295-300.

32) Zeng H, Masuko M, Jin L, Neff T, Otto KG, Blau CA. Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells. Blood 2001, 98:328-334.